Zheng Wei has successfully defended his PhD thesis titled "Field-Resolved Infrared Differential Molecular Fingerprinting"!
Field-resolved infrared spectroscopy probes time-domain molecular vibrational responses that are specific to chemical structure and conformation. In applications such as human plasma analysis, it can provide valuable insights into health and disease. In practice, however, the weak signals of target molecules are often obscured by the intense excitation pulse and the overwhelming response of highly abundant non-signal molecules.
To overcome this limitation, Zheng’s thesis introduces differential molecular fingerprinting (dMF), an interferometric strategy integrated into field-resolved infrared spectroscopy. By employing a broadband achromatic interferometer to suppress dominant background contributions, dMF reduces background interference and enables weak molecular vibrational responses to be observed at earlier times. In this work, the measurement of liquid-phase samples, i.e. protein and plasma, showed the applicability in molecular analytics, with possible biosensing applications.
Congratulations!
Picture: Thorsten Naeser
